The film takes place one year after the events of Captain America: The First Avenger, in which Agent Carter, a member of the Strategic Scientific Reserve, is in search of the mysterious Zodiac.

Chemistry was a sexually explicit comedy-drama series that debuted on Cinemax as a part of its Max After Dark lineup on August 19, 2011. It followed the affair of an attorney and a police officer, which began after the officer saved the attorney from a car wreck. The last episode aired on November 18, 2011.